These conditions may be lethal, including severe arrhythmias, thrombosis, hemorrhage, and disturbed blood pressure (e.g., intracranial hypertension, portal hypertension, caval hypertension, and aortic hypotension), commonly in advanced Virchow triad circumstances [129,130,131,132,133,134,135,136,137,138,139,140,141,142,168]
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212 FBXO31 enhances cisplatin-induced ferroptosis in cholangiocarcinoma cells and stem cell-like cells, and the mechanism may be related to increased GPX4 ubiquitination and proteasome degradation, which could be reversed by GPX4 overexpression